Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer
Manufacturer – Thermo Fisher Scientific
Description: The Q Exactive UHMR combines a high-performance quadrupole for precursor selection with a high-resolution Orbitrap mass analyzer optimized for ultra-high mass range (UHMR) analysis. It is engineered to enable detailed characterization of intact protein assemblies, biotherapeutics and native complexes with high sensitivity and resolution.
Technical Specifications:
Mass range: up to m/z 80,000
Quadrupole precursor selection: up to m/z 25,000
Resolution: up to 200,000 (FWHM) at m/z 400
Scan rate: up to ~12 Hz at 12,500 resolution
Mass accuracy: <1 ppm (internal), <3 ppm (external)
Dynamic range: >5,000:1
Key Features:
• In-source trapping (IST) for efficient transmission and desolvation of high-mass ions
• Advanced Quadrupole Technology (AQT) for precise ion isolation up to very high m/z values
• Optimized ion optics and reduced-frequency RF for improved detection of large macromolecules
• Supports native and top-down MS of intact proteins and complexes
• Designed for exceptional stability, robustness, and sensitivity in UHMR analysis
Applications: Used for native mass spectrometry, top-down proteomics, biotherapeutic and complex protein characterization, and high-mass structural biology research.
Catalog Numbers:
BRE0032850 – 350 to 80,000 m/z – Q-Orbitrap LC-MS Factory Upgrd
0726090 – 350 to 80,000 m/z – Quadrupole-Orbitrap LC-MS
BRE0032840 – 350 to 80,000 m/z – Q-Orbitrap LC-MS Field Upgrade
